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Tempus AI are hiring a Senior Software Engineer I, Transforms Platform

Senior Chicago, Illinois, United States $110k–$160k posted 2026-08-27

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Passionate about precision medicine and advancing the healthcare industry?

Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.

About our Teams:

At Tempus, software and AI products are owned and developed by small, autonomous teams composed of Developers, Designers, Scientists, and Product Managers. You and your team set the goals, build the software, deploy the code, and contribute to a growing software platform that will make a lasting impact in the field of cancer research and treatment.

About the Role:
We’re looking for a Senior Software Engineer I to join the Transforms platform team and help build TransformHub — the service that makes it easy for teams across Tempus to develop, run, and operate batch processing jobs in a highly regulated, HIPAA-compliant environment, without needing to be infrastructure experts.

Transforms are our internal pattern for repeatable compute: structured, documented input goes in; contracted results come out. TransformHub abstracts, standardizes, and automates common and repetitive setup, infrastructure, security, and compliance work so Tempus scientists and engineers can focus on developing their products while the platform handles logging, monitoring, scheduling, resource management, scalability, and integrations.

As a Senior Software Engineer I on the team, you’ll also be driving the platform into its next chapter: extending beyond batch processing into interactive agents — a synchronous, streaming runtime where shipping a code-based chat agent is as simple as registering a repo and opening a PR, with identity, CI/CD, and governance built in — plus cross-system orchestration, parallel execution, and pipelines that compose Transforms into complex data systems.

Your work directly advances Tempus’s mission: AI solutions that empower clinicians to deliver care that helps patients live longer, healthier lives.

Why We’re Looking for You:

Responsibilities:

Required Qualifications:

Bonus Points:

CHI: $110,000-$160,000

The expected salary range may vary for other locations. Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.

We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. 

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